#1 PRESCRIBED BRAND
FOR HEAD LICE1

TARGET THE PEST, NOT THE PERSON

IVERMECTIN: BINDING SELECTIVITY THAT TARGETS PARASITE NERVE AND MUSCLE CELLS2

Treats head lice in minutes2

Ivermectin, a member of the avermectin class, causes paralysis and death of parasites.2

  • Ivermectin is a head lice treatment that works primarily through binding selectively and with high affinity to glutamate-gated chloride channels in invertebrate nerve and muscle cells2

  • This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite2

  • Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA)2

Selectivity of this class is attributable to the fact that2

  • Some mammals do not have glutamate-gated chloride channels2

  • The avermectins have low affinity for mammalian ligand-gated chloride channels2

  • Ivermectin does not readily cross the blood-brain barrier in humans2

Graphic on Mechanism of ActionGraphic on Mechanism of Action

References: 1. Data on file. Arbor Pharmaceuticals, LLC. 2. Sklice Lotion [package insert].

IMPORTANT SAFETY INFORMATION

To prevent accidental ingestion, adult supervision is required for pediatric application. Avoid contact with eyes.

The most common side effects from Sklice Lotion include eye redness or soreness, eye irritation, dandruff, dry skin, and burning sensation of the skin.

Talk with your doctor if you or your child have any side effect that bothers you or that does not go away. You may report side effects to the FDA at 1-800-FDA-1088.

IMPORTANT SAFETY INFORMATION

In order to prevent accidental ingestion, Sklice Lotion should only be administered to pediatric patients under the direct supervision of an adult.

The most common adverse reactions (incidence <1%) include conjunctivitis, ocular hyperemia, eye irritation, dandruff, dry skin, and skin burning sensation.

Please click here for full Prescribing Information for Sklice Lotion.

INDICATION:

Sklice Lotion is a pediculicide indicated for the topical treatment of head lice infestation in patients 6 months of age and older.

ADJUNCTIVE MEASURES:

Sklice Lotion should be used in the context of an overall lice management program:

  • Wash (in hot water) or dry-clean all recently worn clothing, hats, used bedding, and towels.
  • Wash personal care items such as combs, brushes, and hair clips in hot water.

A fine-tooth comb or special nit comb may be used to remove dead lice and nits.